Journal article
Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years
RD Kehm, JM Genkinger, JA Knight, RJ MacInnis, Y Liao, S Li, PC Weideman, WK Chung, AW Kurian, SV Colonna, IL Andrulis, SS Buys, MB Daly, EM John, JL Hopper, MB Terry
Cancer Epidemiology Biomarkers and Prevention | Published : 2025
Abstract
Background: Breast cancer incidence is increasing in women under age 40, underscoring the need for research on breast cancer risk factors for younger women. Methods: We used data from an international family cohort (n ¼ 26,348) to examine whether recreational physical activity (RPA) during adolescence and early adulthood is associated with breast cancer risk before age 40. The cohort includes 2,502 women diagnosed with breast cancer before age 40, including 2,408 diagnosed before study enrollment (68% within 5 years of enrollment). Women reported their average hours per week of moderate and strenuous RPA during adolescence (12–17 years) and early adulthood (25–34 years), which were converted..
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Grants
Awarded by Cancer Council Queensland
Funding Acknowledgements
The six sites of the Breast Cancer Family Registry were supported by grant U01 CA164920 from the US NCI. This work was also supported by grants to kConFab and the kConFab Follow-Up Study from Cancer Australia (grant numbers 809195, 1100868), the Australian National Breast Cancer Foundation (grant number IF 17 kConFab), the National Health and Medical Research Council (grant numbers 454508, 288704, 145684), the NIH (grant number 1RO1CA159868), the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania and South Australia, and the Cancer Foundation of Western Australia (grant numbers not applicable). R.D. Kehm is supported by the NIH and the NCI (grant number R00CA263024). We thank the entire team of Breast Cancer Family Registry past and current investigators as well as the kConFab investigators. We also thank Heather Thorne, Eveline Niedermayr, Lucy Stanhope, Sandra Picken, all the BCFR and kConFab research nurses and staff, the heads and staff of the Family Cancer Clinics, and the many families who contribute to the BCFR and kConFab for their contributions to this resource.